Article
Mismatch repair and cancer susceptibility.
Current opinion in biotechnology - 1 Dec 1994
Kolodner R D, Alani E
Abstract excerpt
Mismatch-repair systems have been identified in organisms ranging from Escherichia coli to humans. They can repair almost all DNA base pair mismatches as well as small insertion/deletion mismatches. Molecular and biochemical analyses have shown that the core components of eukaryotic mismatch-repair systems are highly homologous to their bacterial counterparts. In humans, defects in four mismatch-repair genes have...
Topics
- DNA Repair
- Escherichia coli
- Genetic Predisposition to Disease
- Humans
- Neoplasms
- Nucleic Acid Heteroduplexes
- Saccharomyces cerevisiae