Mismatch repair in correction of replication errors and processing of DNA damage

doi:10.1002/jcp.1067

Article

Mismatch repair in correction of replication errors and processing of DNA damage

27 Feb 2001

Abstract excerpt

The primary role of mismatch repair (MMR) is to maintain genomic stability by removing replication errors from DNA. This repair pathway was originally implicated in human cancer through an association between microsatellite instability in colorectal tumors in hereditary nonpolyposis colon cancer (HNPCC) kindreds. Microsatellites are short repetitive sequences which are often copied incorrectly by DNA polymerases...

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