Article
Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 30 Jan 1995
Radman M, Matic I, Halliday J A, Taddei F
Abstract excerpt
A hereditary form of colon cancer, hereditary non-polyposis colon cancer (HNPCC), is characterized by high instability of short repeated sequences known as microsatellites. Because the genes controlling microsatellite stability were known in bacteria and yeast, as was their evolutionary conservation, the search for human genes responsible for HNPCC became a 'targeted' search for known sequences. Mismatch-repair...
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