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Mammalian DNA Mismatch Repair

1 Dec 1999

Abstract excerpt

DNA mismatch repair (MMR) is one of multiple replication, repair, and recombination processes that are required to maintain genomic stability in prokaryotes and eukaryotes. In the wake of the discoveries that hereditary nonpolyposis colorectal cancer (HNPCC) and other human cancers are associated with mutations in MMR genes, intensive efforts are under way to elucidate the biochemical functions of mammalian MutS...

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PMID: 10690417
DOI: 10.1146/annurev.genet.33.1.533

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