Article
Allelic variants of human TCR BV17S1 defined by restriction fragment length polymorphism, single strand conformation polymorphism, and amplification refractory mutation system analyses.
Human immunology - 1 Sept 1996
Li Y, Sun G R, Zheng Q, Yoo D H, Bhardwaj N, Posnett D N, Crow M K, Friedman S M
Abstract excerpt
Several human TCR BV gene subfamilies, including BV3, BV14, and BV17S1, are single member genes but are overutilized among activated CD4+ synovial T cells in the rheumatoid arthritis (RA). To define the role of these TCR BV genes in the pathogenesis of disease, it is critical to characterize the genomic organization and the allelic variations of these genes. In this study we describe allelic variations of BV17S1...
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