Article
Allelic variants of human TCR BV17S1 defined by restriction fragment length polymorphism, single strand conformation polymorphism, and amplification refractory mutation system analyses.
Human immunology - 1 Sept 1996
Li Y, Sun G R, Zheng Q, Yoo D H, Bhardwaj N, Posnett D N, Crow M K, Friedman S M
Abstract excerpt
Several human TCR BV gene subfamilies, including BV3, BV14, and BV17S1, are single member genes but are overutilized among activated CD4+ synovial T cells in the rheumatoid arthritis (RA). To define the role of these TCR BV genes in the pathogenesis of disease, it is critical to characterize the...
Topics
- Alleles
- Amino Acid Sequence
- Arthritis, Rheumatoid
- Base Sequence
- Gene Amplification
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Amplification Techniques
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single-Stranded Conformational
- Receptors, Antigen, T-Cell, alpha-beta