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Article

Molecular defects in TCRBV genes preclude thymic selection and limit the expressed TCR repertoire.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1996

Currier J R, Yassai M, Robinson M A, Gorski J

Abstract excerpt

A prerequisite for the assembly of a functional TCR is the rearrangement of gene segments to result in in-frame transcripts that can vary in length across the CDR3 region. Selection for in-frame 3-bp spaced rearrangements is observed for functional TCRB genes in thymocyte DNA and mRNA transcripts from PBMC. Previous analyses of the expressed human TCRBV gene repertoire have suggested that BV10S1 and BV19S1 gene...

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PMID: 8683111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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