Molecular defects in TCRBV genes preclude thymic selection and limit the expressed TCR repertoire.

Article

Molecular defects in TCRBV genes preclude thymic selection and limit the expressed TCR repertoire.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1996

Currier J R, Yassai M, Robinson M A, Gorski J

Abstract excerpt

A prerequisite for the assembly of a functional TCR is the rearrangement of gene segments to result in in-frame transcripts that can vary in length across the CDR3 region. Selection for in-frame 3-bp spaced rearrangements is observed for functional TCRB genes in thymocyte DNA and mRNA transcripts...

Topics

Base Sequence
Humans
Molecular Sequence Data
Multigene Family
Mutation
RNA Splicing
RNA, Messenger
Reading Frames
Receptors, Antigen, T-Cell, alpha-beta
Thymus Gland
Transcription, Genetic

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