Article
The human T-cell receptor variable gene segment TCRBV6S1 has two null alleles.
Human immunology - 1 May 1994
Barron K S, Robinson M A
Abstract excerpt
The extent of polymorphism in TCRBV6S1 was examined by screening 203 individuals of diverse ethnic backgrounds by using SSCP. Three alleles were detected, including two that were described previously (TCRBV6S1*1 and *2P). The third allele (TCRBV6S1*3P), identified in these studies, is a pseudogene because, similar to allele *2P, it contains a substitution of a highly conserved cysteine residue near CDR3. Among a...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Genotype
- Humans
- Molecular Sequence Data
- Racial Groups
- Receptors, Antigen, T-Cell