Article
Genomic absence of the gene encoding T cell receptor Vbeta7.2 is linked to the presence of autoantibodies in Sjögren's syndrome.
Arthritis and rheumatism - 1 Jan 2004
Manavalan Sanil J, Valiando Jennifer R, Reeves Westley H, Arnett Frank C, Necker Antje, Simantov Ronit, Lyons Robert, Satoh Minoru, Posnett David N
Abstract excerpt
OBJECTIVE: It is not yet known whether the absence of certain T cell receptor V(beta) (TCRBV) genes (e.g., due to genomic deletion) has functional significance. We examined this question in relation to a known 21.6-kb insertion/deletion-related polymorphism (IDRP) in the human BV locus. METHODS:...
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