Article
Level of human TCRBV3S1 (V beta 3) expression correlates with allelic polymorphism in the spacer region of the recombination signal sequence.
The Journal of experimental medicine - 1 May 1994
Posnett D N, Vissinga C S, Pambuccian C, Wei S, Robinson M A, Kostyu D, Concannon P
Abstract excerpt
One of the causes of variations in the expressed human T cell receptor (TCR) BV (V beta) repertoire is genetic variation in the germline DNA. Herein evidence is provided that allelic polymorphism may affect recombination frequency for a specific V gene. Two alleles of the TCR BV3 differ only at a single nucleotide position (C/T) within the 23-bp spacer region of the recombination signal sequence. These alleles...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- DNA, Ribosomal
- Female
- Humans
- Male
- Molecular Sequence Data
- Pedigree
- Point Mutation
- Polymorphism, Genetic