Article
TCRBV12 genes are polymorphic but the protein products encoded by each gene are conserved.
Human immunology - 1 Jul 1995
Deulofeut H, Wilderson J L, Barron K S, Robinson M A
Abstract excerpt
The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are conservative. Although allelic variants exist for each of the three BV12 genes, only one protein...
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