Article
A functionally significant allelic polymorphism in a T cell receptor V beta gene segment.
European journal of immunology - 1 Jul 1996
Vessey S J, Bell J I, Jakobsen B K
Abstract excerpt
The effect of an allelic polymorphism in the BV1S1 gene segment on recognition of major histocompatibility complex (MHC)-peptide complexes by a specific T cell receptor (TCR) was studied using RBL 2H3 cells transfected with TCR-CD3 zeta chimeric receptors. An HLA-A2-restricted human immunodeficiency virus (HIV) pol-specific cytotoxic T lymphocyte (CTL) clone utilizing the BV1S1A2 gene in combination with AV2S1A2...
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