Article
A functionally significant allelic polymorphism in a T cell receptor V beta gene segment.
European journal of immunology - 1 Jul 1996
Vessey S J, Bell J I, Jakobsen B K
Abstract excerpt
The effect of an allelic polymorphism in the BV1S1 gene segment on recognition of major histocompatibility complex (MHC)-peptide complexes by a specific T cell receptor (TCR) was studied using RBL 2H3 cells transfected with TCR-CD3 zeta chimeric receptors. An HLA-A2-restricted human immunodeficie...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Clone Cells
- Cytotoxicity Tests, Immunologic
- HLA-A2 Antigen
- Humans
- Molecular Sequence Data
- Polymorphism, Genetic
- Rats
- Receptors, Antigen, T-Cell, alpha-beta
- Tumor Cells, Cultured