Article
Analysis of a T-cell receptor V beta segment implicated in susceptibility to rheumatoid arthritis: V beta 2 germline polymorphism does not encode susceptibility.
Annals of the rheumatic diseases - 1 Dec 1993
Pile K, Wordsworth P, Lioté F, Bardin T, Bell J, Cornélis F
Abstract excerpt
OBJECTIVES: The assessment of allelic polymorphism of the T cell receptor gene segment, TCRBV2S1, in rheumatoid arthritis. METHODS: A total of 136 patients with rheumatoid arthritis (RA) (ACR criteria) and 150 controls were TCRBV2S1 genotyped using a nested PCR amplification strategy followed by single-strand conformation polymorphism (SSCP) analysis. RESULTS: The SSCP typing method detected two previously...
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