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Article

Pharmacokinetic evaluation of proguanil: a probe phenotyping drug for the mephenytoin hydroxylase polymorphism.

British journal of clinical pharmacology - 1 Mar 1996

Somogyi A A, Reinhard H A, Bochner F

Abstract excerpt

1. Proguanil (PG) oxidative metabolism to cycloguanil (CG) has been linked to the CYP2C19-mediated genetic polymorphism in S-mephenytoin oxidative metabolism. In many countries, rac-mephenytoin can no longer be administered to humans and hence proguanil may be a more suitable probe for phenotyping purposes. 2. There are limited data on the pharmacokinetics of PG and CG and in particular, whether there is a...

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Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP2C19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

Source

Identifiers

PMID: 8866915
DOI: 10.1111/j.1365-2125.1996.tb00179.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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