Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between CYP2C19 genotype and proguanil oxidative polymorphism.

British journal of clinical pharmacology - 1 Jun 1997

Coller J K, Somogyi A A, Bochner F

Abstract excerpt

AIMS: To examine the relationship between proguanil metabolism and the number of mutations in CYP2C19 by comparing the CYP2C19 genotype and proguanil phenotype of 10 subjects. METHODS: Partial clearance and urinary metabolic ratio data were obtained from a previous study of 10 subjects [5]. Analysis of CYP2C19 genotypes was performed using PCR amplification followed by restriction endonuclease digestion of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Asian People
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Heterozygote

Share to Phenotype

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 9205829
DOI: 10.1046/j.1365-2125.1997.00596.x
PMCID: PMC2042790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between CYP2C19 genotype and proguanil oxidative polymorphism.PMID 9205829Read ↗

Relationship between proguanil metabolic ratio and CYP2C19 genotype in a Caucasian population.Semantic proximity Read ↗

Pharmacokinetic evaluation of proguanil: a probe phenotyping drug for the mephenytoin hydroxylase polymorphism.Semantic proximity Read ↗

Concordance between proguanil phenotype and CYP2C19 genotype in Chinese.Semantic proximity Read ↗

Proguanil metabolism in relation to S-mephenytoin oxidation in a Turkish population.Semantic proximity Read ↗

Influence of the genetic polymorphisms in the 5' flanking and exonic regions of CYP2C19 on proguanil oxidation.Semantic proximity Read ↗

Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutationsSemantic proximity Read ↗

CYP2C19 genotype-phenotype discordance in patients with multiple myeloma leads to an acquired loss of drug-metabolising activity.Semantic proximity Read ↗

Slow chloroguanide metabolism in Tanzanians compared with white subjects and Asian subjects confirms a decreased CYP2C19 activity in relation to genotype.Semantic proximity Read ↗

Simultaneous measurement of proguanil and its metabolites in human plasma and urine by reversed-phase high-performance liquid chromatography, and its preliminary application in relation to genetically determined S-mephenytoin 4'-hydroxylation status.Semantic proximity Read ↗

Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms.Semantic proximity Read ↗

The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study.Semantic proximity Read ↗

Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.