Modified high-performance liquid chromatographic method to measure both dextromethorphan and proguanil for oxidative phenotyping.

doi:10.1016/s0378-4347(97)00225-9

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Article

Modified high-performance liquid chromatographic method to measure both dextromethorphan and proguanil for oxidative phenotyping.

Journal of chromatography. B, Biomedical sciences and applications - 15 Aug 1997

Hoskins J M, Shenfield G M, Gross A S

Abstract excerpt

The activities of the polymorphic enzymes cytochromes P450 2D6 and 2C19 can be assessed by administering the probe drugs, dextromethorphan and proguanil, respectively. An existing high-performance liquid chromatographic technique, which measures dextromethorphan and its metabolites, has been modi...

Topics

Antimalarials
Antitussive Agents
Aryl Hydrocarbon Hydroxylases
Chromatography, High Pressure Liquid
Circadian Rhythm
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Dextromethorphan
Humans
Mixed Function Oxygenases
Osmolar Concentration
Phenotype
Polymorphism, Genetic
Proguanil
Reproducibility of Results
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet

Source

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Identifiers

PMID: 9300912
DOI: 10.1016/s0378-4347(97)00225-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9300912-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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