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Article

The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study.

British journal of clinical pharmacology - 1 Jun 1991

Ward S A, Helsby N A, Skjelbo E, Brøsen K, Gram L F, Breckenridge A M

Abstract excerpt

The activation of the antimalarial drug proguanil (PG) to the active metabolite cycloguanil (CG) has been evaluated in a panel of 18 subjects. These subjects had previously been screened and classified as mephenytoin poor (PMm) or extensive metabolisers (EMm) and sparteine poor (PMs) or extensive metabolisers (EMs). Five subjects had the phenotype PMm/EMs, one was PMm/PMs, six subjects were EMm/PMs and six were...

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Identifiers

PMID: 1867963
DOI: 10.1111/j.1365-2125.1991.tb05594.x
PMCID: PMC1368581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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