Article
Influence of the genetic polymorphisms in the 5' flanking and exonic regions of CYP2C19 on proguanil oxidation.
Drug metabolism and pharmacokinetics - 1 Jan 2009
Satyanarayana Chakradhara Rao Uppugunduri, Devendran Anichavezhi, Jayaraman Muthukumaran, Mannu Jayakanthan, Mathur Premendu P, Gopal Shewade Deepak, Rajagopal Krishnamoorthy, Chandrasekaran Adithan
Abstract excerpt
CYP2C19 is a polymorphic enzyme which metabolizes several clinically important drugs including proguanil. Variation in the 5' regulatory region may influence CYP2C19 activity. This study evaluates the relationship between proguanil metabolic ratio and genetic variations of CYP2C19 in a South Indian population. Fifty unrelated healthy subjects were genotyped for CYP2C19 (*)2 and (*)3 alleles and the 5' flanking...
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