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Article

Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms.

British journal of clinical pharmacology - 1 Aug 1999

Coller J K, Somogyi A A, Bochner F

Abstract excerpt

AIMS: To compare the oxidative metabolism of (S)-mephenytoin and proguanil in vitro and to determine the involvement of various cytochrome P450 isoforms. METHODS: The kinetics of the formation of 4'-hydroxymephenytoin and cycloguanil in human liver microsomes from 10 liver samples were determined, and inhibition of formation was studied using specific chemical inhibitors and monoclonal antibodies directed towards...

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Identifiers

PMID: 10417492
DOI: 10.1046/j.1365-2125.1999.00005.x
PMCID: PMC2014289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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