Article
Proguanil metabolism in relation to S-mephenytoin oxidation in a Turkish population.
British journal of clinical pharmacology - 1 Dec 1996
Basci N E, Bozkurt A, Kortunay S, Isimer A, Sayal A, Kayaalp S O
Abstract excerpt
The oxidation of proguanil was studied in 89 unrelated healthy Turkish volunteers after administration of proguanil (single dose, 200 mg, orally). Based on the distribution of the ratio of proguanil to cycloguanil excreted in urine, and using an antimode value of 15, the prevalence of poor metabo...
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