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Article

Concordance between proguanil phenotype and CYP2C19 genotype in Chinese.

European journal of clinical pharmacology - 1 Nov 2003

Hoskins Janelle M, Shenfield Gillian M, Gross Annette S

Abstract excerpt

OBJECTIVE: To investigate whether urinary proguanil (chlorguanide) metabolite ratios incorporating its minor metabolite, 4-chlorophenylbiguanide, define individuals as extensive metabolisers (EMs) or poor metabolisers (PMs) of CYP2C19 more reliably than the standard phenotyping ratio [proguanil/cycloguanil (PG/CG)]. METHODS: Thirty-eight ethnic Chinese subjects ingested 100 mg proguanil, collected urine for 8 h...

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Identifiers

PMID: 13680037
DOI: 10.1007/s00228-003-0665-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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