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Article

Effect of SLC22A1 polymorphism on the pharmacokinetics of proguanil in Korean: A semi-physiologic population pharmacokinetic approach.

Clinical and translational science - 1 Dec 2024

Khwarg Juyoung, Yang Eunsol, Park Chan Song, Ji Sang Chun, Yu Kyung-Sang, Lee SeungHwan

Abstract excerpt

Proguanil, an antimalarial drug, undergoes hepatic uptake by the polymorphic organic cation transporter 1 (OCT1) and is subsequently metabolized by the cytochrome P-450 2C19 (CYP2C19) enzyme into its active metabolite, cycloguanil. This study aims to evaluate and mechanistically characterize the effect of genetic polymorphism of SLC22A1, which encodes OCT1, on the pharmacokinetics (PKs) of proguanil and...

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Antimalarials
Cytochrome P-450 CYP2C19
East Asian People
Octamer Transcription Factor-1
Proguanil

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Republic of Korea

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Open in PubMed Open full text

Identifiers

PMID: 39668580
DOI: 10.1111/cts.70103
PMCID: PMC11638344

Genes

SLC22A1
CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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