Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark.

doi:10.1111/j.1365-2125.1993.tb04204.x

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Article

Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark.

British journal of clinical pharmacology - 1 Aug 1993

Brøsen K, Skjelbo E, Flachs H

Abstract excerpt

1. A sparteine/mephenytoin phenotyping test was carried out in 37 Vietnamese living in Denmark. By visual inspection the urinary S/R-mephenytoin ratio appeared to show a bimodal frequency distribution. Eight putative poor metabolizers of mephenytoin, PMm (22%), had S/R-mephenytoin ratios from 0.7...

Topics

Administration, Oral
Adult
Biguanides
Denmark
Female
Humans
Male
Mephenytoin
Middle Aged
Oxidation-Reduction
Phenotype
Polymorphism, Genetic
Proguanil
Sparteine
Triazines
Vietnam

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