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Article

Relationship between proguanil metabolic ratio and CYP2C19 genotype in a Caucasian population.

British journal of clinical pharmacology - 1 Nov 1998

Hoskins J M, Shenfield G M, Gross A S

Abstract excerpt

AIMS: To investigate the relationship between proguanil metabolic ratio (MR, proguanil/cycloguanil) and CYP2C19 genotype in a Caucasian population. METHODS: Ninety-nine Caucasians (age range: 18-55 years, 54 female, 45 male) were genotyped for CYP2C19 and phenotyped for proguanil oxidation by collecting urine for 8 h after taking 100 mg proguanil hydrochloride. Proguanil and cycloguanil concentrations were...

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Identifiers

PMID: 9833604
DOI: 10.1046/j.1365-2125.1998.00807.x
PMCID: PMC1873690

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Source receipt: pubmed, retrieved 7 Sept 2026.

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