Article
Relationship between proguanil metabolic ratio and CYP2C19 genotype in a Caucasian population.
British journal of clinical pharmacology - 1 Nov 1998
Hoskins J M, Shenfield G M, Gross A S
Abstract excerpt
AIMS: To investigate the relationship between proguanil metabolic ratio (MR, proguanil/cycloguanil) and CYP2C19 genotype in a Caucasian population. METHODS: Ninety-nine Caucasians (age range: 18-55 years, 54 female, 45 male) were genotyped for CYP2C19 and phenotyped for proguanil oxidation by col...
Topics
- Adolescent
- Adult
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Dextromethorphan
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Middle Aged
- Mixed Function Oxygenases
- Mutation
- Proguanil
- Statistics as Topic
- Triazines
- White People