Article
Chromosome 3p deletions in head and neck carcinomas: statistical ascertainment of allelic loss.
Cancer research - 15 Mar 1992
Latif F, Fivash M, Glenn G, Tory K, Orcutt M L, Hampsch K, Delisio J, Lerman M, Cowan J, Beckett M
Abstract excerpt
Loss of function of tumor suppressor genes is important in the origin and progression of common adult tumors. Loss of heterozygosity indicating allelic loss has been used to detect chromosomal regions that harbor these genes. Using over 20 restriction fragment length polymorphism markers spaced throughout the entire length of chromosome 3p, we have generated 3p allelotypes for 18-26 head and neck squamous cell...
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