Article
Definition of a tumor suppressor gene locus on the short arm of chromosome 3 in squamous cell carcinoma of the head and neck by means of microsatellite markers.
Archives of otolaryngology--head & neck surgery - 1 May 1996
Rowley H, Jones A, Spandidos D, Field J
Abstract excerpt
BACKGROUND: Tumor suppressor genes are important in the development of head and neck cancer. Using microsatellite markers that map close to the region 3p24-pter, we determined the frequency of allele loss close to this site with a view to narrowing the search for a putative tumor suppressor gene...
Topics
- Alleles
- Carcinoma, Squamous Cell
- Chromosomes, Human, Pair 3
- DNA, Neoplasm
- Genes, Tumor Suppressor
- Genetic Carrier Screening
- Genome
- Head and Neck Neoplasms
- Humans
- Hypopharyngeal Neoplasms
- Hypopharynx
- Karyotyping
- Laryngeal Neoplasms
- Larynx
- Microsatellite Repeats
- Mouth
- Mouth Neoplasms
- Oropharyngeal Neoplasms