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Article

Modulation of multidrug resistance in multiple myeloma.

Bailliere's clinical haematology - 1 Dec 1995

Sonneveld P

Abstract excerpt

Primary or acquired drug resistance is the major cause of failure of chemotherapy in MM. MDR is associated with expression of a membrane P-gp, which acts as an efflux pump for natural product drugs, such as doxorubicin and vincristine. P-gp expression is observed in extensively treated patients and is a cause of refractoriness to VAD chemotherapy. Among several other non-cytotoxic drugs, cyclosporins modulate the...

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Identifiers

PMID: 8845575
DOI: 10.1016/s0950-3536(05)80262-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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