P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype.

doi:10.1080/10428190290026277

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Article

P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype.

Leukemia & lymphoma - 1 Jun 2002

Pallis Monica, Turzanski Julie, Higashi Yutaro, Russell Nigel

Abstract excerpt

P-glycoprotein (Pgp) expression is an independent prognostic factor for response to remission-induction chemotherapy in acute myeloblastic leukaemia, particularly in the elderly. There are several potential agents for modulating Pgp-mediated multi-drug resistance, such as cyclosporin A and PSC833, which are currently being evaluated in clinical trials. An alternative therapeutic strategy is to increase the use of...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Acute Disease
Adult
Antineoplastic Agents
Apoptosis
Arsenic Trioxide
Arsenicals
Biological Transport
Cell Division
Ceramides
Child
Cyclosporine
Cyclosporins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance, Multiple

Drug Resistance, Neoplasm

Enzyme Inhibitors

Humans

Hydrogen-Ion Concentration

Source

Open in PubMed

Identifiers

PMID: 12152989
DOI: 10.1080/10428190290026277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.