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Article

Multidrug resistance: clinical relevance in haematological malignancies.

Blood reviews - 1 Mar 1991

Kaye S B, Kerr D J

Abstract excerpt

Multidrug resistance describes an experimental observation which appears to explain cross-resistance to certain structurally unrelated cytotoxic agents, including anthracyclines, vinca alkaloids and podophyllotoxins. It is now clear that a major factor responsible for its development is increased expression of a membrane glycoprotein--P-glycoprotein, which functions as an energy-dependent efflux pump. Recent...

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Identifiers

PMID: 1674435
DOI: 10.1016/0268-960x(91)90006-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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