Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multidrug resistance: clinical relevance in haematological malignancies.

Blood reviews - 1 Mar 1991

Kaye S B, Kerr D J

Abstract excerpt

Multidrug resistance describes an experimental observation which appears to explain cross-resistance to certain structurally unrelated cytotoxic agents, including anthracyclines, vinca alkaloids and podophyllotoxins. It is now clear that a major factor responsible for its development is increased expression of a membrane glycoprotein--P-glycoprotein, which functions as an energy-dependent efflux pump. Recent...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Drug Resistance
Humans
Leukemia
Lymphoma
Membrane Glycoproteins
Multiple Myeloma
Neoplasm Proteins
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1674435
DOI: 10.1016/0268-960x(91)90006-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1674435-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multidrug resistance: clinical relevance in haematological malignancies.PMID 1674435Read ↗

Multidrug resistance mediated by P-glycoprotein in haematological malignancies.Semantic proximity Read ↗

Molecular Targets in Oncology: Implications of the Multidrug Resistance GeneSemantic proximity Read ↗

P-Glycoproteins and Multidrug ResistanceSemantic proximity Read ↗

Multidrug Resistance: Retrospect and Prospects in Anti-Cancer Drug TreatmentSemantic proximity Read ↗

Multidrug resistance in oncology: diagnostic and therapeutic approachesSemantic proximity Read ↗

[Clinical significance of multidrug resistance in acute leukemias].Semantic proximity Read ↗

[Multiple drug resistance--theoretical and clinical aspects].Semantic proximity Read ↗

Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance.Semantic proximity Read ↗

[P glycoprotein and multidrug resistance].Semantic proximity Read ↗

Multidrug Resistance in Cancer: Its Mechanism and its ModulationSemantic proximity Read ↗

Drug resistance in hematologic malignanciesSemantic proximity Read ↗

[MDR (Multiple Drug Resistant) type of resistance to chemotherapy in clinical practice].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.