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Article

Inhibitors of Multidrug Resistance to Antitumor Agents (MDR)

1 Jan 2002

Abstract excerpt

Multidrug resistance is one of the main obstacles in the chemotherapy of cancer. Its inhibition by combination of chemosensitizers with antitumor compounds is a very active field of research, since safe and potent reversal agents would be beneficial for clinical use. Most modulators act by binding to membrane transport proteins (specially P-gp and MRP) and inhibiting their drug-effluxing activity, or by indirect...

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PMID: 11860354
DOI: 10.2174/0929867023371175

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