Article
Multidrug resistance mediated by P-glycoprotein in haematological malignancies.
The Netherlands journal of medicine - 1 Jun 1993
Pasman P C, Schouten H C
Abstract excerpt
The phenomenon that a tumour, resistant to a cytotoxic drug, is also resistant to a large number of other drugs used in cancer chemotherapy, is called multidrug resistance. A transmembrane protein, known as P-glycoprotein (P-gp), is involved in this resistance pattern. P-gp is able to pump large,...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antibiotics, Antineoplastic
- Antineoplastic Agents
- Calcium Channel Blockers
- Calmodulin
- Carrier Proteins
- Cyclosporins
- Drug Resistance
- Gene Expression Regulation, Neoplastic
- Humans
- Leukemia
- Lymphoma
- Membrane Glycoproteins
- Mutation
- Tamoxifen