Article
Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression.
Molecular and cellular biology - 1 Mar 1996
Bennett A M, Hausdorff S F, O'Reilly A M, Freeman R M, Neel B G
Abstract excerpt
Using transient overexpression and microinjection approaches, we examined SHPTP2's function in growth factor signaling. Overexpression of catalytically inactive SHPTP2 (PTP2CS) but not catalytically inactive SHPTP1, inhibited mitogen-activated protein (MAP) kinase activation and Elk-1 transactiva...
Topics
- Animals
- Base Sequence
- Cell Line
- Epidermal Growth Factor
- Gene Expression Regulation
- Intracellular Signaling Peptides and Proteins
- Mice
- Molecular Sequence Data
- Mutation
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases