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Article

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

Genes & development - 1 Apr 1992

Bruder J T, Heidecker G, Rapp U R

Abstract excerpt

Raf-1 serine-threonine protein kinase has the hallmarks of a critical switch that connects growth factor receptor activation at the cell membrane with transcriptional events in the nucleus. We show by use of Raf-1 dominant-negative mutants that Raf-1 is required for serum-, TPA-, and Ras-induced expression from the oncogene-responsive element in the polyomavirus enhancer. The minimal region of Raf-1 that displays...

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Identifiers

PMID: 1313769
DOI: 10.1101/gad.6.4.545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.PMID 1313769Read ↗

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Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters.Semantic proximity Read ↗

Ha-Ras functions downstream from protein kinase C in v-Fps-induced gene expression mediated by TPA response elements.Semantic proximity Read ↗

v-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP-kinase activation.Semantic proximity Read ↗

Cell-specific regulation of oncogene-responsive sequences of the c-fos promoter.Semantic proximity Read ↗

A role for the small GTPase Rac in polyomavirus middle-T antigen-mediated activation of the serum response element and in cell transformation.Semantic proximity Read ↗

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