Article
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.
Genes & development - 1 Apr 1992
Bruder J T, Heidecker G, Rapp U R
Abstract excerpt
Raf-1 serine-threonine protein kinase has the hallmarks of a critical switch that connects growth factor receptor activation at the cell membrane with transcriptional events in the nucleus. We show by use of Raf-1 dominant-negative mutants that Raf-1 is required for serum-, TPA-, and Ras-induced...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- Chloramphenicol O-Acetyltransferase
- Enhancer Elements, Genetic
- Gene Expression
- Genes, Viral
- Genes, ras
- Mice
- Molecular Sequence Data
- Mutation
- Polyomavirus
- Promoter Regions, Genetic
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-raf
- Sequence Homology, Nucleic Acid
- Tetradecanoylphorbol Acetate