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Article

5-Azacytidine-induced 6-thioguanine resistance at the gpt locus in AS52 cells: cellular response.

Environmental and molecular mutagenesis - 1 Jan 1996

Spencer D L, Caspary W J, Hines K C, Tindall K R

Abstract excerpt

Treatment of AS52 cells with 5-azacytidine resulted in an induction of 6-thioguanine-resistant [6TG] colonies, which reached a maximum by an expression time of 9 days. Dose responses for both cytotoxicity and mutation induction were determined following treatment with 5-azacytidine. At 20 microM treatment, 5-azacytidine exposure resulted in about 50% survival. Mutant frequency reached a maximum of 10 microM. At...

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Identifiers

PMID: 8844990
DOI: 10.1002/(SICI)1098-2280(1996)28:2<100::AID-EM5>3.0.CO;2-J

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