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Article

AFB(1) -induced mutagenesis of the gpt gene in AS52 cells.

Environmental and molecular mutagenesis - 1 Aug 2012

Wattanawaraporn Roongtiwa, Kim Min Young, Adams Jillian, Trudel Laura J, Woo Leslie L, Croy Robert G, Essigmann John M, Wogan Gerald N

Abstract excerpt

Aflatoxin B(1) (AFB(1) ) is a potent mutagen and an important risk factor for hepatocellular carcinoma (HCC) in humans. Transgenic mouse strains and cells in culture have been used to detect different types of mutations caused by AFB(1) and investigate the molecular determinants of their location and frequency. The AFB(1) mutational spectrum in the gpt gene was markedly different in AS52 cells compared with the...

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Identifiers

PMID: 22733615
DOI: 10.1002/em.21711
PMCID: PMC3897198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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