Article
5-Azacytidine inhibits the induction of transient TK-deficient cells by 5-bromodeoxyuridine. A novel hypothesis for the facilitation of hypermethylation by 5-bromodeoxyuridine.
Mutation research - 1 May 1991
Call K M, Thilly W G
Abstract excerpt
This paper examines the mechanism by which 5-bromodeoxyuridine (BrdUrd) induces a high frequency of transient trifluorothymidine (F3TdR)-resistant variants in the TK6 human lymphoblast cell line (a TK +/- heterozygote). This phenomenon has previously been termed 'pseudomutation' (Liber et al., 19...
Topics
- Azacitidine
- Bromodeoxyuridine
- Cell Cycle
- Chromatography, High Pressure Liquid
- Cytidine
- DNA
- Deoxycytidine
- Dose-Response Relationship, Drug
- Drug Antagonism
- Gene Expression Regulation
- Humans
- In Vitro Techniques
- Methylation
- Mutation
- Thymidine Kinase