Article
Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus.
Antimicrobial agents and chemotherapy - 1 Aug 1996
Ng E Y, Trucksis M, Hooper D C
Abstract excerpt
Mutations in the flqA (formerly ofx/cfx) resistance locus of Staphylococcus aureus were previously shown to be common after first-step selections for resistance to ciprofloxacin and ofloxacin and to map on the S. aureus chromosome distinctly from gyrA, gyrB, and norA.grlA and grlB, the genes for...
Topics
- Anti-Infective Agents
- Chromosome Mapping
- Chromosomes, Bacterial
- Ciprofloxacin
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Genes, Bacterial
- Microbial Sensitivity Tests
- Mutation
- Ofloxacin
- Polymorphism, Restriction Fragment Length
- Staphylococcus aureus