Article
DX-619, a novel des-fluoro(6) quinolone manifesting low frequency of selection of resistant Staphylococcus aureus mutants: quinolone resistance beyond modification of type II topoisomerases.
Antimicrobial agents and chemotherapy - 1 Dec 2005
Strahilevitz Jacob, Truong-Bolduc Que Chi, Hooper David C
Abstract excerpt
DX-619, a novel des-fluoro(6) quinolone, was 16- to 32-fold, twofold, and four- to eightfold more potent than ciprofloxacin, gemifloxacin, and garenoxacin, respectively, against wild-type Staphylococcus aureus. DX-619 manifested equal fourfold increases in MIC against a common parC mutant and a common gyrA mutant and selected for mutants at up to two- to fourfold its MIC, consistent with dual-targeting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.