Article
Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: novel pleiotropic effects on quinolone and coumarin activity.
Antimicrobial agents and chemotherapy - 1 Jan 1998
Fournier B, Hooper D C
Abstract excerpt
Previous studies have shown that topoisomerase IV and DNA gyrase interact with quinolones and coumarins in different ways. The MICs of coumarins (novobiocin and coumermycin) for MT5, a Staphylococcus aureus nov mutant, are higher than those for wild-type strains. Sequencing the gyrB gene encoding...
Topics
- 4-Quinolones
- Amino Acid Sequence
- Anti-Bacterial Agents
- Anti-Infective Agents
- Anticoagulants
- Coumarins
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Molecular Sequence Data
- Mutation
- Novobiocin
- Phenotype
- Sequence Alignment
- Sequence Homology, Amino Acid
- Staphylococcus aureus