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Article

A novel locus conferring fluoroquinolone resistance in Staphylococcus aureus.

Journal of bacteriology - 1 Sept 1991

Trucksis M, Wolfson J S, Hooper D C

Abstract excerpt

Fluoroquinolones such as ciprofloxacin and ofloxacin are potent antimicrobial agents that antagonize the A subunit of DNA gyrase. We selected and mapped a novel fluoroquinolone resistance gene on the Staphylococcus aureus chromosome. Resistant mutants were selected with ciprofloxacin or ofloxacin and were uniformly localized to the A fragment of chromosomal DNA digested with SmaI and arrayed by pulsed-field gel...

Topics

Anti-Infective Agents
Blotting, Southern
Chromosome Mapping
DNA, Bacterial
Drug Resistance, Microbial
Electrophoresis, Agar Gel
Genes, Bacterial
Genetic Linkage
Molecular Weight
Mutation
Quinolones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Restriction Mapping

Staphylococcus aureus

Source

Open in PubMed Open full text

Identifiers

PMID: 1653224
DOI: 10.1128/jb.173.18.5854-5860.1991
PMCID: PMC208319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1653224-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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