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Article

Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Jul 1995

Ferrero L, Cameron B, Crouzet J

Abstract excerpt

Fluoroquinolone-resistant mutants were obtained in vitro from Staphylococcus aureus RN4220 by stepwise selection on increasing concentrations of ciprofloxacin. Results from sequence analysis of the quinolone resistance-determining region of GyrA and of the corresponding region of GrlA, the DNA topoisomerase IV subunit, showed an alteration of Ser-80 to Tyr (corresponding to Ser-83 of Escherichia coli GyrA) or...

Topics

Ciprofloxacin
DNA Gyrase
DNA Topoisomerase IV
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Genes, Bacterial
Mutation
Norfloxacin
Staphylococcus aureus

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7492103
DOI: 10.1128/AAC.39.7.1554
PMCID: PMC162780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7492103-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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