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Article

Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance.

Cold Spring Harbor perspectives in medicine - 1 Sept 2016

Hooper David C, Jacoby George A

Abstract excerpt

Quinolone antimicrobials are widely used in clinical medicine and are the only current class of agents that directly inhibit bacterial DNA synthesis. Quinolones dually target DNA gyrase and topoisomerase IV binding to specific domains and conformations so as to block DNA strand passage catalysis and stabilize DNA-enzyme complexes that block the DNA replication apparatus and generate double breaks in DNA that...

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Identifiers

PMID: 27449972
DOI: 10.1101/cshperspect.a025320
PMCID: PMC5008060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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