Article
IP3 3-kinase opposes NGF driven neurite outgrowth.
PloS one - 1 Jan 2012
Eva Richard, Bouyoucef-Cherchalli Dalila, Patel Kalpana, Cullen Peter J, Banting George
Abstract excerpt
The inositol (1,4,5) trisphosphate 3-kinases comprise a family of enzymes (A, B, and C) that phosphorylate the calcium mobilising molecule inositol (1,4,5) trisphosphate (IP(3)) to generate inositol (1,3,4,5) tetrakisphosphate. This molecule can function as a second messenger, but its roles are not completely understood. The A isoform of inositol (1,4,5) trisphosphate 3-kinase localises to filamentous actin...
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