IP3 3-kinase opposes NGF driven neurite outgrowth.

doi:10.1371/journal.pone.0032386

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Article

IP3 3-kinase opposes NGF driven neurite outgrowth.

PloS one - 1 Jan 2012

Eva Richard, Bouyoucef-Cherchalli Dalila, Patel Kalpana, Cullen Peter J, Banting George

Abstract excerpt

The inositol (1,4,5) trisphosphate 3-kinases comprise a family of enzymes (A, B, and C) that phosphorylate the calcium mobilising molecule inositol (1,4,5) trisphosphate (IP(3)) to generate inositol (1,3,4,5) tetrakisphosphate. This molecule can function as a second messenger, but its roles are not completely understood. The A isoform of inositol (1,4,5) trisphosphate 3-kinase localises to filamentous actin...

Topics

Actins
Animals
Catalysis
Cell Differentiation
Cell Separation
Extracellular Signal-Regulated MAP Kinases
Flow Cytometry
Green Fluorescent Proteins
Hippocampus
Models, Biological
Nerve Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurites

Neurons

PC12 Cells

Phenotype

Phosphotransferases (Alcohol Group Acceptor)

Rats

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 22384237
DOI: 10.1371/journal.pone.0032386
PMCID: PMC3284567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22384237-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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