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Article

Nerve growth factor stimulates diacylglycerol de novo synthesis and phosphatidylinositol hydrolysis in pheochromocytoma cells.

Brain research - 24 Aug 1998

Li J, Wurtman R J

Abstract excerpt

Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses. To identify the sources of this DAG we examined the effects of NGF treatment on the conversion of [3H]oleic...

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Source

Identifiers

PMID: 9729268
DOI: 10.1016/s0006-8993(98)00595-2

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Nerve growth factor stimulates diacylglycerol de novo synthesis and phosphatidylinositol hydrolysis in pheochromocytoma cells.PMID 9729268Read ↗

Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.Semantic proximity Read ↗

Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase.Semantic proximity Read ↗

Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF.Semantic proximity Read ↗

Phospholipase activity of phospholipase C-gamma1 is required for nerve growth factor-regulated MAP kinase signaling cascade in PC12 cells.Semantic proximity Read ↗

c-Fos activated phospholipid synthesis is required for neurite elongation in differentiating PC12 cells.Semantic proximity Read ↗

Nerve growth factor protects PC12 cells against peroxynitrite-induced apoptosis via a mechanism dependent on phosphatidylinositol 3-kinase.Semantic proximity Read ↗

Nerve growth factor: role in growth, differentiation and controlling cancer cell developmentSemantic proximity Read ↗

NGF-dependent formation of ruffles in PC12D cells required a different pathway from that for neurite outgrowth.Semantic proximity Read ↗

Different roles for RhoA during neurite initiation, elongation, and regeneration in PC12 cells.Semantic proximity Read ↗

IP3 3-kinase opposes NGF driven neurite outgrowth.Semantic proximity Read ↗

NGF induces transient but not sustained activation of ERK in PC12 mutant cells incapable of differentiating.Semantic proximity Read ↗

PC12 variants with altered ornithine decarboxylase expression patterns exhibit altered signal transduction capabilities.Semantic proximity Read ↗

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