Article

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

2019-09-30

Abstract excerpt

Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after development. To better understand this decline whilst aiming to improve regeneration, we focused on phosphoinositide 3-kinase (PI3K) and its product phosphatidylinositol(3,4,5)-trisphosphate (PIP3). We found that neuronal PIP3 decreases with maturity in line...

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Literature Corpus work: 0e4fbc51-f741-5346-9846-c6aa5df6c8d6
DOI: 10.1101/787994

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