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Article

Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.

Molecular and cellular biology - 1 Sept 1991

Thomas S M, Hayes M, D'Arcangelo G, Armstrong R C, Meyer B E, Zilberstein A, Brugge J S, Halegoua S

Abstract excerpt

PC12 cells treated with nerve growth factor (NGF) or infected with Rous sarcoma virus differentiate into sympathetic, neuronlike cells. To compare the differentiation programs induced by NGF and v-src, we have established a PC12 cell line expressing a temperature-sensitive v-src protein. The v-src-expressing PC12 cell line was shown to elaborate neuritic processes in a temperature-inducible manner, indicating...

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Source

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Identifiers

PMID: 1875950
DOI: 10.1128/mcb.11.9.4739-4750.1991
PMCID: PMC361372

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.PMID 1875950Read ↗

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