Article
Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.
Molecular and cellular biology - 1 Sept 1991
Thomas S M, Hayes M, D'Arcangelo G, Armstrong R C, Meyer B E, Zilberstein A, Brugge J S, Halegoua S
Abstract excerpt
PC12 cells treated with nerve growth factor (NGF) or infected with Rous sarcoma virus differentiate into sympathetic, neuronlike cells. To compare the differentiation programs induced by NGF and v-src, we have established a PC12 cell line expressing a temperature-sensitive v-src protein. The v-src-expressing PC12 cell line was shown to elaborate neuritic processes in a temperature-inducible manner, indicating...
Topics
- Cell Count
- Cell Differentiation
- Cell Line
- Gene Expression Regulation
- Genes, src
- Kinetics
- Mutation
- Nerve Growth Factors
- Neurons
- Phosphorylation
- Temperature