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Article

Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling.

Current biology : CB - 5 Feb 2002

van Horck Francis P G, Lavazais Emmanuelle, Eickholt Britta J, Moolenaar Wouter H, Divecha Nullin

Abstract excerpt

Rapid neurite remodeling is fundamental to nervous system development and plasticity and is regulated by Rho family GTPases that signal f-actin reorganization in response to various receptor ligands. Neuronal N1E-115 cells show dramatic neurite retraction and cell rounding in response to serum factors such as lysophosphatidic acid (LPA), sphingosine-1 phosphate (S1P), and thrombin, due to activation of the...

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Source

Identifiers

PMID: 11839279
DOI: 10.1016/s0960-9822(01)00660-1

Genes

LPA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling.PMID 11839279Read ↗

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