Article
Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein.
Science (New York, N.Y.) - 11 Oct 1996
Lefebvre O, Chenard M P, Masson R, Linares J, Dierich A, LeMeur M, Wendling C, Tomasetto C, Chambon P, Rio M C
Abstract excerpt
To determine the function of the pS2 trefoil protein, which is normally expressed in the gastric mucosa, the mouse pS2 (mpS2) gene was inactivated. The antral and pyloric gastric mucosa of mpS2-null mice was dysfunctional and exhibited severe hyperplasia and dysplasia. All homozygous mutant mice...
Topics
- Adenoma
- Animals
- Base Sequence
- Cell Differentiation
- Cloning, Molecular
- Female
- Gastric Mucosa
- Gene Targeting
- Genes, Tumor Suppressor
- Intestinal Mucosa
- Male
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Neoplasm Proteins
- Phenotype
- Proteins
- Pyloric Antrum