Article
Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.
The Journal of biological chemistry - 17 Mar 2006
Kono Mari, Dreier Jennifer L, Ellis Jessica M, Allende Maria L, Kalkofen Danielle N, Sanders Kathleen M, Bielawski Jacek, Bielawska Alicja, Hannun Yusuf A, Proia Richard L
Abstract excerpt
Complex sphingolipids are abundant as eukaryotic cell membrane components, whereas their metabolites, in particular ceramide, sphingosine, and sphingosine 1-phosphate, are involved in diverse cell signaling processes. In mammals, degradation of ceramide by ceramidase yields sphingosine, which is phosphorylated by the action of sphingosine kinase to generate sphingosine 1-phosphate. Therefore, ceramidases are key...
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