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Article

Mice lacking neurofibromin develop gastric hyperplasia.

American journal of physiology. Gastrointestinal and liver physiology - 1 Oct 2009

Lin Lu, Chen Jian, Richardson James A, Parada Luis F

Abstract excerpt

Gastrointestinal (GI) neoplasms are among many manifestations of the genetic disease neurofibromatosis type 1 (NF1). However, the physiological and pathological functions of the Nf1 gene in the GI system have not been fully studied, possibly because of a lack of mouse models. In this study, we generated conditional knockout mice with Nf1 deficiency in the GI tract. These mice develop gastric epithelial...

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Identifiers

PMID: 19661150
DOI: 10.1152/ajpgi.00007.2009
PMCID: PMC2763809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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