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Article

Identification of a Human Mitotic Checkpoint Gene: <i>hsMAD2</i>

11 Oct 1996

Abstract excerpt

In Saccharomyces cerevisiae, MAD2 is required for mitotic arrest if the spindle assembly is perturbed. The human homolog of MAD2 was isolated and shown to be a necessary component of the mitotic checkpoint in HeLa cells by antibody electroporation experiments. Human, or Homo sapiens, MAD2 (hsMAD2) was localized at the kinetochore after chromosome condensation but was no longer observed at the kinetochore in...

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Identifiers

PMID: 8824189
DOI: 10.1126/science.274.5285.246

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Related research

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Research trail→

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